Document 2019
 DOCN  M94A2019
 TI    Host factors in the immunopathogenesis of human immunodeficiency virus
       (HIV) disease.
 DT    9412
 AU    Fauci AS; National Institute of Allergy and Infectious Diseases, NIH,;
       Bethesda, MD 20892.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):4 (abstract no. PS2). Unique
       Identifier : AIDSLINE ICA10/94370556
 AB    A complex array of immunopathogenic mechanisms that are multiphasic and
       multifactorial are involved in the establishment and progression of HIV
       disease. Following primary infection, an acute viremia occurs with wide
       dissemination of HIV. During this early viremic phase, virus enters the
       lymphoid tissue, trapped within the processes of follicular dendritic
       cells. In addition, during this phase of primary infection certain
       patients show major expansions of certain V beta subsets of CD8+ T cells
       which are manifestations of responses to HIV and which may be associated
       with both protective and harmful effects. Thus, events that occur soon
       after initial infection with HIV are critical to the subsequent course
       of HIV disease and may be extremely important in the control of the
       progression of HIV infection. In addition, inappropriate immune
       activation and elevated secretion of certain immunoregulatory cytokines
       occur during HIV infection. These cytokines play a role in the
       regulation of HIV expression in the tissues and, ultimately, influence
       the course of disease. In studies of HIV-infected individuals who are
       long term non-progressors despite up to 11 years of infection, it was
       found that these patients have preserved lymph node architecture, low
       viral burden and viral expression compared to individuals who are
       infected for comparable periods of time, but who progress in their HIV
       disease. The implications of host factors in the immunopathogenesis of
       HIV disease will be discussed.
 DE    Antigens, CD8/IMMUNOLOGY  Cytokines/IMMUNOLOGY/SECRETION  Dendritic
       Cells/IMMUNOLOGY  Human  HIV Infections/*IMMUNOLOGY  Lymphocyte
       Subsets/*IMMUNOLOGY  Precipitating Factors  T-Lymphocytes/IMMUNOLOGY
       Viremia/IMMUNOLOGY  MEETING ABSTRACT

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